Purpose:To investigate the condition and change of corneal blindness (CB) in the past 30 years.Methods: 1 001 blinding patients of corneal disease were clinically analysed from 1960 to 1989,including etiology, sex, age, occupation, difference between the urban and rural areas etc.Results: The male predominated. Infection stood the first cause of blinding corneal diseases, followed by trauma,malnutrition and the others.HSV-1 keratitis was the most frequent infection in 1980s. The highest incidence of CB was 20-40 year -old. The number of CB caused by occupational truauma was more than that by ordinary trauma in 1960s,but from 1970s, the latter was more than the former. The number of CB in rural area was more than that in the urban in 1960s,but from 1970s,there was no significant difference between the two areas. The percentage of bilateral CB was gradually decreased.Conclusion: We should try to find more effective strategies to prevent and treat CB caused by HSV-1 keratitis, pay special attention to pres Purpose: To investigate the condition and change of corneal blindness (CB) in the past 30 years. Methods: 1 001 blinding patients of corneal disease were clinically analyzed from 1960 to 1989, including etiology, sex, age, occupation, difference between the urban and rural areas etc.Results: The male predominated. Infection stood the first cause of blinding corneal diseases, followed by trauma, malnutrition and the others. HSV-1 keratitis was the most frequent infection in 1980s. The highest incidence of CB was 20- The number of CB caused by occupational truauma was more than that by ordinary motoruma was 1960s, but from 1970s, the latter was more than the former. The number of CB was occupied in occupational truauma was more than that by ordinary trauma in 1960s, but from 1970s, the latter was more than the former. The percentage of bilateral CB was most decreased.Conclusion: We should try to find more effective strategies to prevent and treat CB caused by HSV-1 keratitis, pay special attention to pres