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目的评价湖南省2001~2005年急性弛缓性麻痹(AFP)病例病毒学监测情况,巩固无脊髓灰质炎(脊灰)成果。方法收集<15岁AFP病例粪便标本,采用世界卫生组织规定方法进行肠道病毒(EV)分离与鉴定,脊灰病毒阳性株送中国疾病预防控制中心病毒病预防控制所国家脊灰实验室进行型内鉴别。结果5年共检测1 103例AFP病例粪便标本(2 185份),EV分离阳性276例,未发现脊灰野病毒,分离到疫苗相关脊灰病毒112例,疫苗变异脊灰病毒6例,疫苗相关脊灰病毒与非脊灰肠道病毒(NPEV)混合4例,NPEV 154例。结论湖南省2001~2005年未发现脊灰野病毒,维持了无脊灰状态。但监测发现疫苗变异脊灰病毒6例,必须采取有效措施阻止可能的疫苗衍生脊灰病毒的循环和爆发。
Objective To evaluate the virological status of acute flaccid paralysis (AFP) cases in Hunan Province from 2001 to 2005 and to consolidate the achievements of poliomyelitis-free (poliomyelitis). Methods Stool samples of AFP cases aged <15 years were collected and isolated by Enterovirus (EV) method according to the WHO method. The positive strains of poliovirus were sent to the National Polio Laboratory for Disease Prevention and Control of Chinese Center for Disease Control and Prevention Within the identification. Results A total of 1 103 cases of AFP cases stool samples (2 185) were detected in 5 years and 276 were EV positive. No poliovirus was found. One hundred and twelve vaccine-associated poliovirus Poliovirus and non-polio enterovirus (NPEV) mixed in 4 cases, 154 cases of NPEV. Conclusion No wild poliovirus was found in Hunan Province from 2001 to 2005, maintaining the polio-free status. However, the surveillance found that 6 cases of the vaccine mutation poliovirus must take effective measures to prevent the possible cycle and outbreak of vaccine-derived poliovirus.