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本实验以下丘脑单胺类神经递质为指标,对不同月龄、喂以不同补益中药的雄性大鼠进行分组对照观察,结果发现:①23月龄雄性大鼠下丘脑基底部去甲肾上腺素(NE)和多巴胺(DA)的含量明显低于3月龄雄性大鼠;②补肾益气方能明显延缓23月龄雄性大鼠下丘脑基底部NE和DA含量的降低。而健脾益气方仅能延缓NE含量的降低;③补肾益气方能提高23月龄雄性大鼠下丘脑基底部5-羟色胺(5-HT)和5-羟吲哚乙酸(5-HIAA)的含量,5-HIAA升高更为显著。而健脾益气方仅能提高5-HIAA的含量。
In this experiment, hypothalamic monoamine neurotransmitters were used as indicators. Grouped and controlled observations were conducted on male rats of different months of age and fed with different tonic herbs. The results showed that norepinephrine was present in the hypothalamus of male rats at 123 months of age. The content of NE) and dopamine (DA) was significantly lower than that of 3-month-old male rats; 2 Bushen Yiqi Decoction significantly delayed the decrease of NE and DA contents in the hypothalamus of the 23-month-old male rats. However, Spleen-Qi-Yi Prescription can only delay the decrease of NE content; 3 Bushen Yiqi Prescription can improve 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the hypothalamic basal of 23-month-old male rats. ), 5-HIAA increased more significantly. The spleen and qi can only increase the content of 5-HIAA.