非小细胞肺癌(NSCLC)是肺癌的一种,它具有极高的病死率。在NSCLC的发生、发展中丝裂原活化蛋白激酶(MAPK)通路异常激活起重要作用,而B-Raf基因是MAPK通路中MEK/ERK最为关键的激活因子,进而对肿瘤细胞的增殖、分化和凋亡等方面起作用。B-Raf基因表达异常存在于NSCLC中并影响它的发生及预后,针对B-Raf基因的靶向治疗是一个新的研究热点。 Non-small cell lung cancer (NSCLC) is a type of lung cancer that has a very high case fatality rate. In NSCLC, the abnormal activation of mitogen-activated protein kinase (MAPK) pathway plays an important role in the development of NSCLC, and B-Raf gene is the most crucial activator of MEK / ERK in MAPK pathway, which further affects the proliferation and differentiation of tumor cells Apoptosis and other aspects. The abnormal expression of B-Raf gene exists in NSCLC and affects its occurrence and prognosis. Targeting B-Raf gene therapy is a new research hotspot.