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目的：探索醒脑静注射液治疗中枢意识障碍的临床疗效。方法：采用随机分组对照法，将１０４例意识障碍患者分为醒脑静组（治疗组）６３例，清开灵组（对照组）４１例，进行疗效对比分析。结果：治疗组治愈２８例，显效２２例，有效６例，总有效率８８．８９％；对照组治愈１０例，显效８例，有效１２例，总有效率７３．１７％，２组疗效差异有显著性（Ｐ＜０．０５）。从时效关系分析，治疗组的起效时间明显快于对照组（Ｐ＜０．０５），且其达到最大效应的时间明显短于对照组（Ｐ＜０．０５）；从证效关系分析，醒脑静注射液对痰热内闭型的疗效优于痰浊内盛型（Ｐ＜０．０２５）；而量效关系则提示醒脑静注射液的治疗效果与剂量呈正相关。结论：醒脑静注射液具有醒脑止痉、清热凉血、行气活血和解毒止痛等功效，是防治意识障碍的安全、有效药物。
Objective: To explore the clinical effect of Xingnaojing Injection in treating central disturbance of consciousness. Methods: A total of 104 patients with disturbance of consciousness were divided into Xingnaojing group (treatment group), 63 cases and Qingkailing group (control group), 41 cases were compared by randomized controlled group. Results: In the treatment group, 28 cases were cured, 22 cases were markedly effective, 6 cases were effective, and the total effective rate was 88.89%. In the control group, 10 cases were cured, 8 cases markedly effective and 12 cases effective. The total effective rate was 73.17% There was significant (P <0.05). From the time-effect analysis, the onset time of the treatment group was significantly faster than that of the control group (P <0.05), and the time to reach the maximum effect was significantly shorter than that of the control group (P <0.05) The effect of Xingnaojing injection on endophthalmitis of phlegm was better than that of Phlegm-turbidity (P <0.025), while the dose-response relationship suggested that the therapeutic effect of Xingnaojing injection was positively correlated with the dosage. Conclusion: Xingnaojing Injection has the functions of Xingnao Zhijing, Qingre Liangxuan, Qi and blood circulation and detoxification and analgesia, which is a safe and effective drug for prevention and treatment of disturbance of consciousness.