目的:建立测定茶多酚缓释胶囊中表没食子儿茶素没食子酸酯含量的高效液相色谱法。方法:采用Kromasil C18(250 mm×4.6 mm5,μm)的色谱柱;以甲醇-0.1%甲酸水溶液(70∶30)为流动相;流速:1.0 mL/min;检测波长:280 nm;柱温为30℃。结果:表没食子儿茶素没食子酸酯在1.5175～9.105μg范围内与峰面积分别呈良好的线性关系(r=0.9997,n=6),平均回收率是100.2%(RSD=0.5%)。结论:该方法简便、准确、专属性强,可用于该制剂的质量控制。 OBJECTIVE: To establish a HPLC method for the determination of epigallocatechin gallate in tea polyphenols sustained release capsules. Methods: The column with Kromasil C18 (250 mm × 4.6 mm 5, μm) was used. The mobile phase consisted of methanol-0.1% formic acid solution (70:30), the flow rate was 1.0 mL / min, the detection wavelength was 280 nm, 30 ° C. Results: The epigallocatechin gallate showed a good linear relationship with the peak area in the range of 1.5175-9.105μg (r = 0.9997, n = 6). The average recovery was 100.2% (RSD = 0.5%). Conclusion: The method is simple, accurate and specific and can be used for the quality control of the preparation.