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目的:探讨子宫内膜异位症患者保守性手术后给与GnRH-α退缩疗法临床疗效及对内分泌的影响。方法:选择2003年1月~2005年1月在我院行保守性手术治疗的子宫内膜异位症患者30例,术后给予GnRH-α退缩疗法。对照组20例,术后不服用任何药物。分析GnRH-α退缩疗法治疗子宫内膜异位症的疗效、副反应及对垂体-卵巢轴内分泌的影响。结果:两组患者痛经症状均得到不同程度缓解,给药组缓解率为86.7%,明显高于对照组55%,差异有统计学意义(P<0.05),给药组复发率为6.7%,低于对照组15%,结果有统计学意义(P<0.05)。结论:给予GnRH-α退缩疗法巩固治疗子宫内膜异位症有一定的临床疗效,可预防和减少复发,而且副反应小,对内分泌代谢及骨密度无明显影响。
Objective: To investigate the clinical efficacy and endocrine effects of GnRH-α withdrawal therapy after conservative surgery in patients with endometriosis. Methods: Thirty patients with endometriosis who underwent conservative surgery in our hospital from January 2003 to January 2005 were enrolled in this study. GnRH-α withdrawal therapy was given after operation. Control group of 20 patients, do not take any medication after surgery. The curative effect of GnRH-α withdrawal therapy on endometriosis, side effects and the effect on endocrine of pituitary-ovarian axis were analyzed. Results: The symptoms of dysmenorrhea in both groups were alleviated to some extent. The remission rate was 86.7% in the treatment group and 55% in the control group (P <0.05), and the recurrence rate was 6.7% 15% lower than the control group, the result was statistically significant (P <0.05). CONCLUSION: GnRH-α regurgitation treatment has certain clinical efficacy in the treatment of endometriosis. It can prevent and reduce recurrence, and has little side effects. It has no significant effect on endocrine metabolism and bone mineral density.