探讨外源性一氧化氮 (NO)吸入对高原人体运动后血液流变学的影响。方法 :对进驻海拨 41 0 0m高原 2 0天的 2 0名健康青年随机分为吸入NO ( 1 0ppm)组和对照组 (口服炒面胶囊 ) ,每组 1 0人。在吸入NO前、吸入NO 6天后踏阶运动前后分别检测血中红细胞压积 (HCT)、血液粘度 ( ηb)、血浆粘度( ηp)、还原粘度 ( ηr)、红细胞刚性指数(IR)、红细胞变形系数 (TK)、红细胞聚集系数 (VAI)及血栓形成系数 (TFL)含量。结果 :吸入NO前运动后较运动前 ,对照组和吸入NO组HCT、ηb、ηp、ηr、IR、TK、VAI、TFL均降低 (P <0 0 5或 0 0 1 ) ;吸入NO后运动后较运动前对照组各指标均降低 ,吸入NO组HCT、ηb、ηp、ηr、TK、VAI降低 (P<0 0 5或 0 0 1 ) ,IR、TFL无统计学意义 (P>0 0 5)。运动前及运动后吸入NO后较吸入前 ,对照组均无统计学差异 (P >0 0 5) ;吸入NO组运动前吸入后较吸入前ηb、ηp、IR降低

0 0 5)。结论 :吸入低浓度NO对运动机体可发挥有效的保护作用 To investigate the effect of exogenous nitric oxide (NO) inhalation on hemorheology after high altitude exercise. Methods: Twenty healthy youths who were stationed in an altitude of 4100m above sea level were randomly divided into inhaled NO (10ppm) group and control group (oral fried noodles), with 10 in each group. Before inhalation of NO, the levels of hematocrit (HCT), blood viscosity (ηb), plasma viscosity (ηp), reducing viscosity (ηr), erythrocyte rigidity index (IR) (TK), erythrocyte aggregation coefficient (VAI) and thrombus formation factor (TFL). Results: Before inhalation of NO, the HCT, ηb, ηp, ηr, IR, TK, VAI and TFL of control group and inhaled NO group were decreased (P <0.05 or 0.01) The index of HCT, ηb, ηp, ηr, TK, VAI decreased (P 0 05 or 0 0 1), but there was no significant difference of IR and TFL between before and after exercise 5). There was no significant difference in the levels of ηb, ηp and IR before inhalation of NO before inhalation (P> 0.05) before inhaling NO before exercise and before exercise after inhalation. (P <0 05 or 0 0 1), while the rest had no statistical significance (P 0 05). Conclusion: Inhaled low concentration of NO can play an effective protective effect on the body of exercise