有人提出在复合性煤工尘肺的发展过程中未确定的宿主因素是重要的,至少这些因素之一可能包含有免疫应答。对各煤矿工人的研究提供了支持这一观点的证据,包括抗核抗体和类风湿因子占优势的特异性变异的报导,肺抗体反应在疾病病因方面所起的牵连作用,以及某些人对进行性大块行纤维化的明显增加的感受性。 It is important to point out that undetermined host factors during the development of a complex coal worker’s pneumoconiosis may be involved, at least one of these factors may contain an immune response. Evidence of support for the coal miners’ research is provided, including reports of specific mutations predominant of antinuclear and rheumatoid factors, the implicated role of pulmonary antibody responses in the etiology of the disease, Significantly increased susceptibility to progressive chorionic fibrosis.