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在胰腺癌细胞系和胰腺原发肿瘤中 ,β 连接素和E 钙粘着蛋白的表达常常缺失 ,且 β 连接素表达的缺失比E 钙粘蛋白表达的缺失更为常见。利用不表达 β 连接素和E 钙粘着蛋白的人类胰腺癌细胞系MiaPaca 2和具有侵袭、运动能力的乳腺癌细胞系HS785T作为阳性对照 ,通过免疫荧光法
The expression of β-catenin and E-cadherin is often absent in pancreatic cancer cell lines and primary pancreatic tumors, and the loss of β-catenin expression is more common than the loss of E-cadherin expression. MiaPaca 2, a human pancreatic cancer cell line that does not express β-catenin and E-cadherin, and HS785T, an invasive and motor-competent breast cancer cell line, were used as positive controls and immunofluorescence