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目的了解合肥市流行性脑脊髓膜炎(简称流脑)菌群变迁情况,为流脑防治工作提供依据。方法对合肥市2000年至2012年流脑疫情和健康人群监测资料进行回顾性分析。结果 2003年前,流脑病人主要由A群脑膜炎奈瑟菌引起(Nm)。健康人群带菌主要是B群Nm,其次为A群。2003～2012年流脑患者菌群,C群占93.0%,A群占6.0%,B群和W135占1.0%;健康人群带菌以C群和B群为主,分别为2.5%和1.6%。2011年出现由W135群引起的流脑死亡病例。结论 2003～2012年,合肥市流脑流行优势菌群从A群Nm转变为C群,C群菌群Nm仍将在一段时间内是优势菌群,而W135群和B群为辅。
Objective To understand the population change of epidemic cerebrospinal meningitis in Hefei City (referred to as meningitis), and provide the basis for prevention and control of meningococcal disease. Methods A retrospective analysis was conducted on surveillance data of epidemic encephalitis and healthy people from 2000 to 2012 in Hefei City. Results Before 2003, patients with meningitis were mainly caused by Neisseria meningitides group A (Nm). Healthy population is mainly B group Nm, followed by A group. From 2003 to 2012, the population of patients with meningitis was 93.0% for group C, 6.0% for group A, 1.0% for group B and W135, and 2.5% and 1.6% for group C and group B, respectively. In 2011 there were cases of mesiobol death caused by the W135 group. Conclusion From 2003 to 2012, the prevalence of meningitis in Hefei was changed from Nm A to C, while Nm C of C increased to be the dominant bacteria for a period of time, while W135 and B were supplemented.