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目的对新生儿ABO溶血病患儿进行新生儿神经行为测定(NBNA),评价高胆红素血症对神经系统造成的影响以及早期干预治疗的临床价值。方法选取本院48例ABO溶血病高胆红素血症患儿为观察组,根据胆红素水平分为轻度、中重度两组。选取同期自然分娩、健康无黄疸的足月儿30例为对照组。两组分别于出生后的2-3d、7-10d以及26-28d时进行NBNA测定,对结果进行比较与分析。结果中重度组黄疸高峰期NBNA评分明显低于对照组,差异具有统计学意义(P<0.05),中重度组黄疸消退期及轻度组黄疸高峰与消退期NBNA评分与对照组差异无统计学意义(P>0.05)。结论新生儿ABO溶血病高胆红素血症患儿中重度组黄疸高峰期对神经系统有影响。
OBJECTIVE: To evaluate neonatal neurobehavior (NBNA) in neonates with ABO hemolytic disease and to evaluate the effects of hyperbilirubinemia on the nervous system and the clinical value of early intervention. Methods Select 48 cases of ABO hemolytic disease in children with hyperbilirubinemia as observation group, according to bilirubin levels were divided into mild, moderate and severe groups. Select the same period of natural childbirth, healthy jaundice in 30 cases of full-term children as the control group. NBNA was measured at 2-3 days, 7-10 days and 26-28 days after birth in both groups, and the results were compared and analyzed. Results The peak NBNA score of jaundice in moderate and severe group was significantly lower than that in control group (P <0.05). There was no significant difference in NBNA score between jaundice exacerbation group and mild jaundice group and control group Significance (P> 0.05). Conclusion Neonatal ABO hemolytic disease hyperbilirubinaemia in children with moderate and severe jaundice peak period on the nervous system.