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目的:探讨薄层液基细胞学技术及TBS(The Besthesda system)诊断系统诊断宫颈癌及癌前病变的相关因素及临床细胞学特点。方法:对1 678例受检者的宫颈脱落细胞采用液基薄层细胞(TCT)检测和TBS分类诊断,将不典型鳞状上皮细胞(ASC-US)以上病变列为细胞学阳性病例,分析不同宫颈病变及其与临床的关系。结果:1 678例受检者TCT标本满意率为96.36%,细胞学阳性病例206例,总检出率12.28%。其中ASC-US+不典型腺上皮细胞(AGUS)占6.32%;低度鳞状上皮内病变(LSIL)占2.74%;高度鳞状上皮内病变(HSIL)占3.10%;鳞状细胞癌和腺癌(CA)占0.12%;人乳头瘤病毒(HPV)感染174例(10.37%)。在206例TCT阳性病例中,宫颈光滑-轻度糜烂与中-重度糜烂各占50.00%,正常或轻度炎组占34.95%,中度炎组占27.67%,重度炎组占32.52%。结论:TCT和TBS系统能准确反映宫颈病变情况,HPV是宫颈上皮内瘤样病变(CIN)的重要相关因素,预防HPV感染、筛查和监测HPV感染对象、治疗及阻止CIN病变升级是防止宫颈癌的关键。
Objective: To investigate the related factors and clinical cytology characteristics of thin-section liquid-based cytology and TBS (The Besthesda system) diagnostic system for cervical cancer and precancerous lesions. Methods: The cervical exfoliated cells of 1 678 subjects were diagnosed by TCT and TBS. The above lesions of atypical squamous cell (ASC-US) were classified as cytology-positive cases. Different cervical lesions and its relationship with clinical. Results: The satisfaction rate of TCT specimens was 96.36% in 1 678 subjects and 206 in cytology positive subjects, the total detection rate was 12.28%. Among them, ASCUS + atypical glandular epithelial cells (AGUS) accounted for 6.32%, low-grade squamous intraepithelial lesion (LSIL) accounted for 2.74%, high grade squamous intraepithelial lesion (HSIL) accounted for 3.10%, squamous cell carcinoma and adenocarcinoma (CA) accounted for 0.12%; human papillomavirus (HPV) infection in 174 cases (10.37%). Cervical smooth-mild erosion and moderate-severe erosion accounted for 50.00%, 34.95% in normal or mild inflammation group, 27.67% in moderate inflammation group and 32.52% in severe inflammation group in 206 TCT positive cases. Conclusion: TCT and TBS system can accurately reflect the cervical lesions, HPV is an important factor related to cervical intraepithelial neoplasia (CIN), prevention of HPV infection, screening and monitoring of HPV infection, treatment and prevention of cervical lesions is to prevent the upgrade of cervical The key to cancer.