甲状腺机能减退(甲减)与高胆固醇血症有关,并且是动脉粥样硬化发生的危险因素之一。在以往的实验中,作者曾发现甲减鼠的高密度脂蛋白(HDL)血浆清除率下降。鉴于肝脏是HDL-胆固醇分解的一个重要场所,本文探讨了甲状腺素缺乏时是否影响HDL与肝细胞的结合。 实验用雄性Wistar鼠,喂以丙基硫氧嘧啶(PTU,0.1%w/w),使鼠发生甲减。应用胶原酶缓冲 Hypothyroidism (hypothyroidism) is associated with hypercholesterolemia and is one of the risk factors for atherosclerosis. In previous experiments, the authors found that plasma HDL clearance in hypothyroidism decreased. Since the liver is an important site of HDL-cholesterol breakdown, this article explores whether thyroid hormone deficiency affects the binding of HDL to hepatocytes. Male Wistar rats were experimentally challenged with hypothyroidism with propylthiouracil (PTU, 0.1% w / w). Apply collagenase buffer