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报告自体骨髓移植治疗白血病39例,其中非净化自体骨髓移植(ABMT)14例,净化自体骨髓移植(PABMT)25例。中位年龄28岁(10~43岁)。AML27例,ALL10例,CML2例。CR131例,CR27例,NR1例。CR至移植时间中位数6.7个月(2~19个月)。预处理方案:TBI加Ara-c、DNR或VP16。ABMT组及PABMT组3年无病生存(DFS)率分别为68.32%及67.57%,复发率为30.76%及26.80%。但PABMT组AML患者3年DFS率为82.35%及CR2期移75%3年DFS率为75%,明显高于CR。期移植未净化者50%。化疗组3年DFS率为7.38%及复发率76.4%,两移植组疗效优于化疗组。
Reports 39 cases of leukemia treated with autologous bone marrow transplantation, including 14 cases of uncleaned autologous bone marrow transplantation (ABMT) and 25 cases of autologous bone marrow transplantation (PABMT). The median age is 28 years (10 to 43 years old). There were 27 cases of AML, 10 cases of ALL, and 2 cases of CML. CR 131 cases, CR 27 cases, NR 1 cases. The median time from CR to transplantation was 6.7 months (2 to 19 months). Pretreatment plan: TBI plus Ara-c, DNR, or VP16. The 3-year disease-free survival (DFS) rates in the ABMT and PABMT groups were 68.32% and 67.57%, respectively, and the recurrence rates were 30.76% and 26.80%. However, the 3-year DFS rate in patients with AML in the PABMT group was 82.35% and the CR2 shift was 75%. The 3-year DFS rate was 75%, which was significantly higher than CR. Transplanted untreated 50%. The 3-year DFS rate in the chemotherapy group was 7.38% and the recurrence rate was 76.4%. The efficacy of the two-transplantation group was better than that of the chemotherapy group.