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目的:探讨早发型重度子痫前期终止妊娠时机与围生结局的关系;进一步研究如何选择最佳时机终止妊娠以保证母婴安全。方法:回顾2005年8月～2010年8月间89例早发型重度子痫前期患者,将其分为2组,A组为积极治疗及时终止妊娠组,B组为期待治疗8天以上终止妊娠组,比较两组围生结局。结果:A组39例终止妊娠孕周31周±5.6天,围生儿死亡率69.2%,B组50例终止妊娠孕周32周±9.1天,围生儿死亡率10.0%,B组的围生儿死亡率、新生儿窒息率和NICU住院率均低于A组(P<0.05),B组的新生儿状况明显好于A组(P<0.01)。结论:选择合适的早发型重度子痫前期孕妇进行期待治疗,可以改善围生儿结局,孕产妇的结局也是安全的。
OBJECTIVE: To investigate the relationship between the timing of termination of pregnancy and the outcome of early-onset severe preeclampsia and to further study how to choose the best time to terminate the pregnancy to ensure the safety of mother and infant. Methods: From August 2005 to August 2010, 89 patients with early-onset severe preeclampsia were retrospectively divided into two groups: group A received active treatment for termination of pregnancy in time, and group B received treatment for termination of pregnancy for more than 8 days Group, compared two groups of perinatal outcome. Results: In group A, the termination of pregnancy gestational weeks 31 weeks ± 5.6 days, perinatal mortality rate 69.2%, group B 50 weeks termination of gestational weeks 32 weeks ± 9.1 days, perinatal mortality rate 10.0%, group B circumference Neonatal mortality, neonatal asphyxia and NICU hospitalization rates were lower than those in group A (P <0.05). The neonatal status in group B was significantly better than that in group A (P <0.01). CONCLUSIONS: Choosing the right early-onset severe preeclampsia for expectant treatment will improve perinatal outcome and maternal outcomes are also safe.