目的观察长期苯妥英钠（ＤＰＨ）治疗对癫痫儿童牙齿生长发育的影响。方法把１８８例长期单服ＤＰＨ的患者按开始服的年龄分为乳牙组（Ａ组），换牙组（Ｂ组）及恒牙组（Ｃ组）。比较三组牙齿的色泽、排列、形状、乳牙滞留、恒牙萌出异常以及与齿龈增生的关系。结果三组牙异常发生率分别为３７２１％、３３３３％及８３３％，Ａ、Ｂ组明显高于Ｃ组；Ａ组较Ｂ组严重，但两组间无统计学意义的差异。１１例停药后随访３年以上，未见明显改善。结论换牙前接受ＤＰＨ治疗，牙的生长发育将会受到影响，并对牙齿带来难以逆转的影响，因此对儿童选用ＤＰＨ时应十分慎重。 Objective To observe the effect of long-term phenytoin sodium (DPH) treatment on the growth of children with epilepsy. Methods 188 cases of long-term single-serving DPH patients were divided into primary teeth group (A group), changing teeth group (B group) and permanent teeth group (C group). The color, arrangement, shape, retention of deciduous teeth, eruption of permanent teeth and the relationship with gingival hyperplasia were compared among the three groups of teeth. Results The incidences of abnormal teeth in three groups were 3721%, 3333% and 8.33% respectively, while those in group A and B were significantly higher than those in group C. A group was more severe than group B, but there was no significant difference between the two groups difference. 11 cases were followed up for more than 3 years after stopping, no significant improvement. Conclusion DPH treatment before tooth exchange will have an impact on the growth and development of the tooth and will have an irreversible effect on the tooth. Therefore, care should be taken when selecting DPH for children.