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目的研究地特胰岛素替代低精蛋白胰岛素(NPH)治疗T2DM的效果。方法用地特胰岛素替代NPH治疗30例T2DM患者,检测HbA_1c、FBG及患者个体FBG变异性,体重变化以及低血糖发生率。检测时间包括在替代前12周,替代后3个阶段(每阶段均为12周)。结果 HbA_1c在第2、3阶段明显改善。体重从62.7 kg降至61.3 kg(第1阶段),FBG明显改善,患者个体FBG变异性比使用NPH时低。结论使用地特胰岛素能良好地控制血糖,短时间体重并未增加。
Objective To investigate the effect of insulin detemir instead of hypopirulin (NPH) on T2DM. Methods 30 patients with T2DM were treated with insulin instead of NPH to detect the changes of FBG, FBG and individual FBG, body weight and the incidence of hypoglycemia. Detection time was included in the first 12 weeks of replacement, after the replacement of the three stages (each stage is 12 weeks). Results HbA_1c was significantly improved in stages 2 and 3. Weight decreased from 62.7 kg to 61.3 kg (stage 1), FBG improved significantly, and patient individual FBG variability was lower than with NPH. Conclusion Use of insulin detemir can be a good control of blood glucose, short-term weight did not increase.