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目的:观察不同剂量卡介苗膀胱灌注联合中药治疗浅表性膀胱肿瘤术后患者的复发与不良反应情况。方法:将198例浅表性膀胱肿瘤术后患者按卡介苗灌注剂量分为3组,分别接受120 mg、60 mg和30 mg 3种不同剂量的卡介苗膀胱灌注,随访6~24月,选取临床和随访资料完整的病例,观察肿瘤复发和不良反应发生情况。结果:60 mg组患者的膀胱灌注不良反应较120mg组轻(P<0.05),肿瘤复发率低于30 mg组(P<0.05)。结论:卡介苗灌注剂量为60 mg时不良反应更轻,肿瘤复发率更低。
Objective: To observe the recurrence and adverse reactions of intravesical instillation of different doses of BCG combined with traditional Chinese medicine in patients with superficial bladder tumor. Methods: Ninety-eight patients with superficial bladder tumor were divided into three groups according to the BCG infusion dose. Three groups of different doses of 120 mg, 60 mg and 30 mg BCG were given respectively. The patients were followed up for 6-24 months, Follow-up data complete case, observed tumor recurrence and adverse reactions. Results: The urinary perfusion adverse reaction in 60 mg group was lighter than that in 120 mg group (P <0.05), and the recurrence rate of tumor was lower than that in 30 mg group (P <0.05). CONCLUSION: BCG at a dose of 60 mg has less adverse reactions and lower tumor recurrence rate.