目的　分析儿童畸胎瘤的临床病理特点。方法　回顾 80例儿童畸胎瘤的光镜检查、免疫组化甲胎蛋白 (AFP)染色以及临床资料。结果　成熟畸胎瘤 6 0例 (75 0 % ) ,术前血AFP阳性 7例 ,组织免疫组化AFP弱阳性 1例 ;未成熟畸胎瘤 11例 (13 8% ) ,术前血清及组织免疫组化AFP均为阳性 10例 ;恶性畸胎瘤 9例 (11 2 % ) ,术前血清及组织AFP均为阳性 8例。结论　儿童畸胎瘤的生物学良恶性应在病理组织形态的基础上 ,结合患儿年龄、AFP值、肿瘤部位进行综合分析。 Objective To analyze the clinicopathological features of teratoma in children. Methods 80 cases of teratoma were retrospectively examined by light microscopy, immunohistochemical AFP staining and clinical data. Results Sixty cases of mature teratoma (75 0%), 7 cases of AFP positive preoperative blood, 1 case of immunohistochemical AFP weakly positive, 11 cases of immature teratoma (13.8%), preoperative serum and tissue Immunohistochemical AFP were positive in 10 cases; malignant teratoma in 9 cases (11 2%), preoperative serum and tissue AFP were positive in 8 cases. Conclusion The biological benign and malignant infantile teratoma should be based on the pathological morphology, combined with children’s age, AFP value, the tumor site for a comprehensive analysis.