目的作者旨在探讨，简便、可靠，特异的检测手段，发现和防治幽门螺杆菌（Ｈｐ）感染．方法取患者牙周粘膜，放入快速尿素酶检测试剂中，阳性者建议内镜检查，取胃粘膜作快速尿素酶检测，同时取末梢血２０μｌ，用ＥＬＩＳＡ法检测血清Ｈｐ抗体滴度，以观察其相关性．结果通过口腔检测１００例，牙周炎７８例，阳性３２例（４１０％），冠周炎２２例，阳性７例（３１８％），胃粘膜检测阳性３５例（６０３％），本组检测结果，牙周粘膜Ｈｐ阳性３９０％，胃粘膜Ｈｐ阳性６０３％．结论口腔粘膜检测为我们早期，简便诊断Ｈｐ感染，建立了一个新方法． The purpose of the authors aimed to explore, simple, reliable and specific detection means, detection and prevention and treatment of Helicobacter pylori (Hp) infection. Methods The patient’s periodontal mucosa was taken and placed in rapid urease test reagent. Positive patients recommended endoscopy, gastric mucosa for rapid urease test, taking the peripheral blood 20μl, ELISA to detect serum Hp antibody titers to observe Its relevance. Results There were 100 cases of oral cavity disease, 78 cases of periodontitis, 32 cases (410%) positive, 22 cases of pericoronitis, 7 cases (318%) positive, 35 cases (603% ), The test results of this group, periodontal mucosa Hp positive 39  0%, gastric mucosa Hp positive 60  3%. Conclusion Oral mucosa testing for our early diagnosis of Hp infection, the establishment of a new method.