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对２０例正常人、２０例慢性阻塞性肺病（慢阻肺）及２５例慢性阻塞性肺病呼吸衰竭（慢阻肺呼衰）患者进行潮气末二氧化碳分压（ＰｅｔＣＯ２）和动脉血二氧化碳分压（ＰａＣＯ２）对比研究，并与死腔气量／潮气容积（ＶＤ／ＶＴ）和气道阻力（Ｒａｗ）进行相关分析。结果表明，正常组及慢阻肺组ＰａＣＯ２和ＰｅｔＣＯ２间无明显差异（Ｐ＞０．０５），ＰｅｔＣＯ２可反映ＰａＣＯ２变化。慢阻肺呼衰者ＰａＣＯ２和ＰｅｔＣＯ２间有明显差异，其中ＰｅｔＣＯ２较ＰａＣＯ２低，平均相差达２．１３ｋＰａ±１．２６ｋＰａ（Ｐ＜０．０１）。故在慢阻肺呼衰时ＰｅｔＣＯ２不能反映ＰａＣＯ２变化，此时如以ＰｅｔＣＯ２来估计ＰａＣＯ２是不可靠的。慢阻肺呼衰时ＰａＣＯ２－ＰｅｔＣＯ２之差异与ＶＤ／ＶＴ（ｒ＝０．８１，Ｐ＜０．０１）和Ｒａｗ相关（ｒ＝０．４２，Ｐ＜０．０５）。
Twenty patients with normal COPD, 20 chronic obstructive pulmonary disease (COPD) and 25 patients with chronic obstructive pulmonary disease (COPD) underwent respiratory gas pressure (PetCO2) and arterial partial pressure of carbon dioxide PaCO2), and correlated with dead space volume / tidal volume (VD / VT) and airway resistance (Raw). The results showed that there was no significant difference between PaCO2 and PetCO2 in normal group and COPD group (P> 0.05), and PetCO2 could reflect PaCO2 change. There was a significant difference between PaCO2 and PetCO2 in COPD patients, in which PetCO2 was lower than PaCO2 with an average difference of 2.13 kPa ± 1.26 kPa (P <0.01). Therefore, PetCO2 can not reflect the change of PaCO2 when COPD is slow, at this time, it is unreliable to estimate PaCO2 with PetCO2. The difference of PaCO2-PetCO2 in chronic obstructive pulmonary disease was correlated with VD / VT (r = 0.81, P <0.01) and Raw (r = 0.42, P <0.05).