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神经肽与胺类递质共存于同一神经原,并都有相应的突触后受体,因而推想这些物质可能有突触后相互作用。作者选择内脏神经与肾上腺髓质嗜铬细胞间的突触进行研究,因为内脏神经纤维含有乙酰胆碱和多分子型脑啡肽样多肽,嗜铬细胞膜有乙酰胆碱和阿片肽受体。当阿片受体与特异激动剂结合后,它能抑制胆碱能受体与乙酰胆碱的结合能力及儿茶酚胺的释放。因而提出共存于内脏神经中的肽及乙酰胆碱可能有辅递质作用,以调制乙酰胆碱受体的敏感性。
Neuropeptides and amine neurotransmitters co-exist in the same neuron, and have the corresponding postsynaptic receptors, suggesting that these substances may have postsynaptic interactions. The authors chose to study the synapses between the visceral nerves and the adrenal medullary chromaffin cells because the visceral nerve fibers contain acetylcholine and multimodal enkephalin-like peptides, and acetylcholine and opioid receptors in the chromaffin cell membranes. When opioid receptor binding with specific agonists, it can inhibit the cholinergic receptors and acetylcholine binding capacity and catecholamine release. It is proposed that coexistence of visceral nerves in the peptide and acetylcholine may have a secondary neurotransmitter to modulate the sensitivity of acetylcholine receptors.