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早期研究表明,使用含左旋18甲基炔诺酮(LNG)避孕可出现血清性激素结合球蛋白(SHBG)下降。这种下降被认为是由于LNG的雄激素活性所致。即LNG对SHBG合成的直接影响或是由于它从载体蛋白上替代了睾酮而抑制SHBG浓度的间接作用或者两种因素的综合。在内源性高雄激素妇女中存在高胰岛素血症,胰岛素通过抑制肝脏产生SHBG而导致血清SHBG水平降低。曾有报道,含LNG的复方避孕药也可增加胰腺胰岛素分泌。胰岛素样生长因子结合蛋白
Early studies have shown that there is a drop in serum sex hormone binding globulin (SHBG) using contraceptives containing levonorgestrel 18 (LNG). This decline is thought to be due to the androgenic activity of LNG. Ie, the direct effect of LNG on SHBG synthesis or the indirect effect of inhibiting SHBG concentration due to its replacement of testosterone from the carrier protein or the combination of both. Hyperinsulinemia is present in endogenous hyperandrogenate women, and insulin decreases serum SHBG levels by inhibiting the production of SHBG in the liver. It has been reported that LNG-containing compound birth control pills can also increase pancreatic insulin secretion. Insulin-like growth factor binding protein