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研究了Ｎ－甲基－３－羟基吡啶盐与丙烯腈的１，３－偶极环加成反应．由环合产物经过氢化，还原得包公藤甲素的中间体８－甲基－２β－羟基－８－氮二环［３．２．１］辛烷－６－ｅｘｏ－腈．本合成路线具有高立体选择性．
The 1,3-dipolar cycloaddition reaction of N-methyl-3-hydroxypyridinium salt with acrylonitrile was studied. The cyclization product is hydrogenated and reduced to give 8-methyl-2β-hydroxy-8-azoniabicyclo [3.2.1] octane-6-exo-nitrile, which is an intermediate of the triptolide. The synthetic route has high stereoselectivity.