论文部分内容阅读
糖尿病肾病是糖尿病主要晚期并发症之一 ,细胞培养、动物实验及人体研究都证实转化生长因子 β(TGF β)在糖尿病肾病发生发展中起了重要作用。本文阐述糖尿病状态下导致TGF β升高的因素 ,并介绍TGF β在糖尿病肾病病理改变中的作用及针对TGF β研究的临床意义。
Diabetic nephropathy is one of the major late complications of diabetes. Cell culture, animal experiments and human studies have confirmed that transforming growth factor β (TGFβ) plays an important role in the development of diabetic nephropathy. This article describes the factors that lead to the elevation of TGF-β in diabetic conditions and introduces the role of TGF-β in the pathological changes of diabetic nephropathy and the clinical significance of TGFβ.