Objective: To explore the clinical effect of Chinese medicine aerosol fumigation on demodex infection related meibomian gland dysfunction. Methods: In this prospective study,60 patients(120 eyes) were selected and randomly divided into 2 groups: the treatment group(30 cases, 60 eyes) was treated with Chinese medicine aerosol fumigation and meibomian gland massage, the control group(30 cases, 60 eyes) was treated with meibomian gland massage. Observation of Demodex count, symptom scores ,break-up time (BUT), Schirmer I test (SIT), meibomian gland secretion function scores and eyelid fat traits scores were used to compare the difference between before and after treatment. Results: There was no significant difference in Demodex count, symptom scores ,BUT, SIT, meibomian gland secretion function scores and eyelid fat traits scores between the 2 groups before treatment(P>0.05).After treatment, symptom scores ,meibomian gland secretion function scores and eyelid fat traits and Demodex count of the treatment group were significantly reduced(P<0.01). Conclusion: Chinese medicine aerosol fumigation can relieve symptoms of of demodex infection related meibomian gland dysfunctionand reduce the number of ocular Demodex.