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随着IC RP26、32号出版物的发表,微剂量学概念的应用,在氡子体剂量一效应关系研究中出现了一些新概念。这些概念把宏观与观微、物理量与生物量结合起来,试图在微观部位中建立剂量-效应关系的模型,这给微观水平上定量地研究氡子体的生物效应提出了一些新课题。天然氡子体暴露的肺剂量及其致癌危险受到很大重视,一些计算结果表明一般居民中的肺癌可能有20%来自天然氡照射。近年氡致肺癌的大批动物实验结果提供了关于肺癌潜伏期、剂量率效应、剂量-效应关系图形、单位WLM 肺癌危险和复合因素作用等方面的资料,很多与铀矿工肺癌流行病学研究结果相一致。
With the publication of IC RP 26, No. 32 and the application of the concept of micro-dosimetry, new concepts have emerged in the dose-response relationship studies of radon progeny. These concepts combine macroscopical, microscopic, physical and biological quantities, trying to establish a dose-effect relationship model in the microscopic part, which puts forward some new topics for quantitatively studying the biological effects of radon progeny on the microscopic level. Much attention has been given to the lung dose and carcinogenic risk of natural radon progeny. Some calculations show that 20% of the lung cancer in the general population may come from natural radon irradiation. In recent years, a large number of animal experimental results of lung cancer caused by radon have provided information on the latent period of lung cancer, dose rate effect, dose-response relationship graph, unit WLM risk of lung cancer and the role of multiple factors, many of which are consistent with the results of epidemiological studies of lung cancer in uranium miners .