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目的探讨白细胞介素－Ｉ（ＩＬ—Ｉ）的水平与胃癌发病的关系。方法应用生物反应测定法对２７例胃癌、１５例胃溃疡、１６例慢性表浅性胃炎，１８例慢性萎缩性胃炎及２２例正常人的血清和组织培养上清液ＩＬ—Ｉ活性进行进行了测定．结果胃癌患者血清和组织中ＩＬ—Ｉ水平均低于正常人，也低于胃良性病变组；胃溃病组织中ＩＬ—Ｉ水平低于正常人，但高于胃癌组织。结论胃癌的发生可能与ＩＬ—Ｉ水平低下有关。胃溃汤组织中ＩＬ－Ｉ低下可能是其癌变的因素之一。
Objective To investigate the relationship between the level of interleukin-l (IL-I) and the pathogenesis of gastric cancer. Methods The activity of IL-1 in serum and tissue culture supernatants of 27 cases of gastric cancer, 15 cases of gastric ulcer, 16 cases of chronic superficial gastritis, 18 cases of chronic atrophic gastritis and 22 cases of normal human serum were measured by biological reaction method. Determination. Results The levels of IL-1 in serum and tissues of gastric cancer patients were lower than normal and lower than those in benign gastric lesions. The levels of IL-1 in gastric ulcer tissues were lower than those in normal subjects, but higher than those in gastric cancer tissues. Conclusion The occurrence of gastric cancer may be related to the low level of IL-I. Lower IL-I in Stomach ulcer tissue may be one of the factors of canceration.