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对８５例ＩｇＡ肾病行肾穿刺活检免疫组织化学检查，肾组织中乙肝病毒抗原（ＨＢＶＡｇ）阳性共２６例（３０．５９％）。肾组织中ＨＢＶＡｇ阳性组与阴性组相比：血红蛋白、肌酐清除率明显下降，２４小时尿蛋白定量显著增加，肾组织病理改变中硬化肾小球数、间质炎症和血管炎显著增加（Ｐ＜０．０５）。随访期内阳性组有２例（７．６９％）进入尿毒症期而行透析治疗。肾组织ＨＢＶＡｇ阳性组与阴性组临床表现、病理改变及预后有明显差异，对阳性组病人进行抗病毒治疗尤为重要。
Totally 85 cases of IgA nephropathy were examined by biopsy with renal biopsy, and 26 cases (30.59%) were positive for hepatitis B virus antigen (HBVAg) in renal tissues. Compared with the negative group, HBeAg-positive group showed significantly decreased hemoglobin, creatinine clearance, 24-hour urinary protein, significantly increased renal pathological changes in glomerular number, interstitial inflammation and vasculitis (P < 0.05). During the follow-up period, 2 patients (7.69%) in the positive group entered the uremia period and received dialysis treatment. The clinical manifestations, pathological changes and prognosis of HBVAg-positive and -negative groups in renal tissue were significantly different, and it was especially important for antiviral treatment in patients with positive group.