通过动物实验发现,大多数常见的滴耳药均可导致感音神经性聋及毛细胞的破坏。Ciprofloxacin,环丙氟哌酸是一种相对较新的fluoroquinolone类药物,具有强烈地对抗绿脓杆菌和耐新霉素I的白色葡萄球菌的作用。最近的研究表明口服Ciprofloxacin对慢性浆液性中耳炎和恶性外耳道炎有疗效。然而,到目前为止该药还从未用作滴耳剂。以35只白色雌豚鼠用于研究盐酸Ciprofloxacin局部滴耳时的耳毒性。将药物输送管置于动物双侧的听泡。于用 Animal experiments found that most common ear drops can lead to sensorineural deafness and hair cell destruction. Ciprofloxacin, a relatively new fluoroquinolone drug, has a potent anti-Pseudomonas aeruginosa and neomycin-resistant Staphylococcus aureus. Recent studies have shown that oral Ciprofloxacin is effective in treating chronic serous otitis media and malignant otitis externa. However, so far the drug has never been used as ear drops. 35 white female guinea pigs were used to study the ototoxicity of topical ear drops of Ciprofloxacin hydrochloride. The drug delivery tube placed on both sides of animals to listen to the bubble. In use