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近十年来,在药理学研究的各个领域普遍应用了同位素。特别在心血管药物的研究中,目前已积累了大量资料,在阐明药物的作用原理、探索其代谢规律等方面发挥了较大的作用,其中有些课题如血容量、循环时、总体水量的测定以及外源性与内源性物质代谢等,都是应用一般方法难以解决的。本文试就同位素在阐明心血管药物作用原理方面的一些应用情况作一概要介绍。冠状动脉血流量的测定冠状动脉循环担负着营养心肌的重要任务。高血压等疾患时由于心肌肥厚常导致心肌相对缺血,而冠状动脉心脏病患者心肌缺血现象更为严重。为了寻找防治冠状动脉心脏病或高血压的有效药物,观察药物对冠状动脉循环的影响是重要的课题之一。血液动力学研究表明,血压加倍时流量只增加一倍,而血管床的平均口径加倍时流量将增加16倍。因此观察冠状动脉循环的变化多以血流
In the past decade, isotopes have been widely used in various fields of pharmacological research. Especially in the study of cardiovascular drugs, a large amount of data has been accumulated so far, which has played a significant role in clarifying the principle of the drug and exploring its metabolic regulation. Some of the topics such as blood volume, circulation, total amount of water, and Exogenous and endogenous material metabolism, etc., are difficult to solve using the general method. This article attempts to elucidate some of the applications of isotopes in elucidating the role of cardiovascular drugs. Determination of coronary blood flow Coronary circulation plays an important role in the maintenance of cardiac muscle. Hypertension and other diseases often lead to myocardial ischemia due to myocardial hypertrophy, and myocardial ischemia in patients with coronary heart disease is more serious. In order to find effective drugs for prevention and treatment of coronary heart disease or hypertension, it is one of the important topics to observe the effects of drugs on coronary circulation. Hemodynamic studies show that when the blood pressure doubled only double the flow, and the average diameter of the vascular bed doubling the flow will increase 16 times. Therefore, changes observed in coronary circulation more than blood flow