论文部分内容阅读
对１１６例酒精性肝病（ＡＬＤ）肝穿标本进行了病理观察。其中具肝细胞脂变者９９例，占８５％。依脂变程度将其分为Ⅰ～Ⅳ级，脂变肝细胞≥３０％诊断为酒精性脂肪肝（ＡＦＬ）。Ⅰ级：脂变肝细胞＜小叶３０％；Ⅱ级：＞３０％（轻度ＡＦＬ，１９例）；Ⅲ级：＞５０％（中度ＡＦＬ，６例）；Ⅳ级：≥７０％（重度ＡＦＬ，２例）。对酒精性肝脂变的特点进行了观察：轻者呈散在或小灶状大泡状脂变，主要分布于小叶的Ⅱ区和Ⅲ区，严重者脂变甚弥漫，脂变处网状支架多完整保存，常同时伴有ＡＬＤ其它一些基本病变，如窦周纤维化、小坏死灶及小型肝细胞等。以上病理特点有利于从病理上与其它原因所致肝脂变进行鉴别。
116 cases of alcoholic liver disease (ALD) liver biopsy specimens were observed. Among them, there are 99 cases of hepatocellular lipidosis, accounting for 85%. According to the degree of lipid change, the patients were divided into Ⅰ ~ Ⅳ grade, fatty liver≥30%, diagnosed as alcoholic fatty liver (AFL). Grade Ⅰ: fatty liver cells <30% of leaflets; grade Ⅱ:> 30% (mild AFL, 19 cases); grade Ⅲ:> 50% (moderate AFL, 6 cases) AFL, 2 cases). The characteristics of alcoholic hepatic steatosis were observed: the light was scattered or small lamellar vesicular fat lesions, mainly in the Ⅱ and Ⅲ lobular area, the fat is even more diffuse, steatotic network stent more Complete preservation, often accompanied by ALD some other basic lesions, such as sinus fibrosis, small necrotic lesions and small hepatocytes. The above pathological features are helpful to distinguish hepatic steatosis from other pathological reasons.