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卵泡的成熟、排卵及黄体形成都受到黄体生成素(LH)的调控,LH 系通过特异的细胞膜受体作用于被膜细胞、颗粒细胞和黄体细胞。动物和人类卵泡细胞呈现 LH 受体浓度升高恰与卵泡成熟一致,说明颗粒细胞上出现 LH 受体为排卵和黄体化所必需的条件。近年发现,多囊卵巢病患者成熟卵泡上的LH 受体数量减少伴有无排卵及不育。不育患者中有30～40%是由于内膜异位症,这可能与无排卵和孕酮分泌延迟有关。因此,作者测定了成熟卵泡和黄体上 LH 受体的浓度,以期探索在内膜异位症时LH 的作用机理。选择51例21～46岁的盆腔内膜异位症患者,其中39例有卵巢定位,余12例卵巢健康。按美国生育协会分类,其中28例为轻度或中度,另28例为重度内膜异位。于手术时取下最大的卵泡或新鲜黄体,立即置
Follicle maturation, ovulation and luteal formation are regulated by luteinizing hormone (LH). LH acts on envelope cells, granulosa cells and luteal cells via specific cell membrane receptors. The rise of LH receptor concentrations in animal and human follicular cells coincided with the maturation of follicles, indicating that LH receptors on granulosa cells are required for ovulation and luteinization. In recent years, polycystic ovary patients found that mature follicles on the LH receptor decreased with no ovulation and infertility. 30-40% of infertile patients are due to endometriosis, which may be related to anovulation and delayed progesterone secretion. Therefore, the authors measured the concentration of LH receptors on mature follicles and corpus luteum in order to explore the mechanism of action of LH during endometriosis. Fifty-one patients with pelvic endometriosis between the ages of 21 and 46 years were selected, of whom 39 had ovarian localization and the remaining 12 had ovarian health. According to the American Fertility Association classification, 28 cases were mild or moderate, and the other 28 cases were severe endometriosis. Remove the largest follicle or fresh luteal during surgery and immediately set