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毒蕈碱型乙酰胆碱受体在机体分布广泛,作用重要。目前对其亚型中的毒蕈碱型乙酰胆碱受体1、毒簟碱型乙酰胆碱受体2受体研究较多,但对毒蕈碱型乙酰胆碱受体3受体的研究,特别在呼吸系统疾病中的表达尚处在起步阶段。毒蕈碱型乙酰胆碱受体3受体广泛分布在气道平滑肌和腺体上,研究表明毒蕈碱型乙酰胆碱受体3受体的改变可影响气道疾病的严重程度与治疗效能。因此,寻找特异性、高度选择性的毒蕈碱型乙酰胆碱受体3受体拮抗剂,将是今后开始治疗呼吸系统疾病专用新药的又一突破口。
Muscarinic acetylcholine receptors are widely distributed in the body, the role of important. At present, there are many studies on the muscarinic acetylcholine receptor 1 and the toxoid acetylcholine receptor 2 receptors in their subtypes, but studies on the muscarinic acetylcholine receptor 3 receptor, especially in respiratory diseases The expression is still in its infancy. Muscarinic acetylcholine receptor 3 receptors are widely distributed in airway smooth muscle and gland, studies have shown that muscarinic acetylcholine receptor 3 receptor changes can affect the severity of airway disease and therapeutic efficacy. Therefore, looking for a specific and highly selective muscarinic acetylcholine receptor 3 receptor antagonist, will be another breakthrough in the future for the treatment of new drugs for respiratory diseases.