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目的探讨中枢神经系统感染（ＣＮＳＩ）时血浆与脑脊液（ＣＳＦ）中内皮素（ＥＴ）的变化。方法采用放射免疫法测定６６例ＣＮＳＩ患者血浆和ＣＳＦ中的ＥＴ－１水平。结果ＣＮＳＩ患者ＣＳＦ中的水平较对照组高，对照组与病毒脑、结脑组相比有显著性差异（Ｐ分别＜０．００１、０．０５），与化脑组相比无显著性差异（Ｐ＞０．０５），血浆中的水平与ＣＮＳＩ关系不明显（Ｐ＞０．０５）；ＣＮＳＩ伴重度脑功能障碍者ＣＳＦ和血浆中ＥＴ－１水平明显高于伴轻中度脑功能障碍者（Ｐ＜０．００１）或无脑功能障碍者（Ｐ＜０．００１），轻中度脑功能障碍又明显高于无脑功能障碍者（Ｐ＜０．００１）。结论ＣＳＦ和血浆中ＥＴ－１水平与ＣＮＳＩ的病种无关，而与脑损伤的程度有关，其含量增高可作脑实质损伤的重要指标，ＥＴ－１可能是脑实质损伤的重要因素
Objective To investigate the changes of endothelin (ET) in plasma and cerebrospinal fluid (CSF) during central nervous system infection (CNSI). Methods The levels of ET-1 in plasma and CSF of 66 patients with CNSI were determined by radioimmunoassay. Results The level of CSF in CNSI patients was higher than that in control group, and there was significant difference between control group and virus brain and tuberculin group (P <0.001, 0.05 respectively), but no significant difference (P> 0.05). There was no significant correlation between plasma levels and CNSI (P> 0.05). The levels of CSF and plasma ET-1 in patients with CNSI complicated with severe brain dysfunction were significantly higher than those with mild to moderate brain dysfunction (P <0.001) or those without brain dysfunction (P <0.001). The mild to moderate brain dysfunction was significantly higher than those without brain dysfunction (P <0.001). Conclusions ET-1 level in CSF and plasma is not related to CNSI disease, but is related to the degree of brain injury. Increased levels of ET-1 may be an important index of brain injury. ET-1 may be an important factor in brain injury