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目的:探讨稳定期慢性阻塞性肺疾病(COPD)患者凝血状态的变化及与炎症反应的关系。方法:检测30例稳定期COPD患者及25名健康体检者血清D-二聚体(D-D)、纤维蛋白原(FIB)、凝血酶原片段1+2(F1+2)及C反应蛋白(CRP)水平,同时进行诱导痰细胞计数检测。结果:COPD组血清D-D、FIB、F1+2及CRP水平均显著高于健康对照组(P<0.01或P<0.05);COPD组诱导痰细胞总数、中性粒细胞计数及百分比均明显高于健康对照组;COPD组血清D-D、FIB、F1+2浓度与CPR水平及诱导痰中性粒细胞数均呈显著正相关(P<0.01或P<0.05)。结论:稳定期COPD患者凝血机制发生改变,处于高凝状态,且凝血状态的改变与气道局部及全身炎症反应密切相关。
Objective: To investigate the changes of coagulation status in patients with chronic obstructive pulmonary disease (COPD) and its relationship with inflammatory reaction. Methods: Serum D-dimer (DD), fibrinogen (FIB), prothrombin fragment 1 + 2 (F1 + 2) and C reactive protein (CRP) were detected in 30 stable COPD patients and 25 healthy volunteers. ) Level, at the same time induced sputum cell count test. Results: The serum levels of DD, FIB, F1 + 2 and CRP in COPD group were significantly higher than those in healthy control group (P <0.01 or P <0.05). The total number of induced sputum cells, neutrophil count and percentage in COPD group were significantly higher than those in control group In healthy control group, the serum levels of DD, FIB and F1 + 2 in COPD group were positively correlated with CPR level and induced sputum neutrophil count (P <0.01 or P <0.05). Conclusion: The coagulation mechanism of patients with stable COPD changes in hypercoagulable state, and the change of coagulation state is closely related to local and systemic airway inflammation.