细菌感染,特别是慢性细菌感染一直是临床治疗中困扰医师的一个棘手问题。自1 9世纪末德国科学家罗伯特·科赫发现细菌与人类疾病的相互关系后,人类就一直致力于与感染性疾病的斗争。在抗菌药物问世之前,人类一直遭受细菌等病原体疾病的煎熬,人们在庆幸一代又一代新型广谱高效抗 Bacterial infections, especially chronic bacterial infections, have been a thorny issue for physicians who are plagued by clinical treatments. Since the discovery of the interplay between bacteria and human diseases by the German scientist Robert Koch in the late 19th century, humans have been fighting the battle against infectious diseases. Before the advent of antibacterial drugs, humans have been suffering from pathogenic diseases such as bacteria, people are fortunate to generation after generation of new broad-spectrum high-efficiency