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本工作选用标仪，成年雄性ｗｉｓｔａｒ大鼠。以放射免疫测定法（ＲＩＡ），研究了大鼠由平原（海拔５ｍ，上海）引入高原环境（海拔３４６０ｍ）后，在２４小时内急性习服期，垂体及各脑区β－内啡肽样免疫活性物质（βｐ－ＥＰＬＩ）的含量变化。结果表明：大鼠在高原２４小时急性习服期，高原实验组与平原对照组相比，垂体内β－ＥＰ含量降低非常显著（Ｐ＜０．０１）。纹状体、下丘脑、丘脑、桥延、海马，中脑内β－ＥＰ含量增加非常显著（Ｐ＜０．０１）。据此证实，急性高原低氧环境能影响垂体β－ＥＰ的分泌与释放。提示，脑内β－ＥＰＬＩ参与高原低氧的应激反应过程。可能作为神经递质和调质，通过神经－内分泌环路在应激反应中起介导作用，β－ＥＰ可能为中枢神经系统内调节应激反应的主要应激激素之一。
This work selected standard equipment, adult male wistar rats. The radioimmunoassay (RIA) was used to investigate the effects of acute appetite, pituitary and brain β-endorphin-like activity in rats after a plateau (altitude 5m, Shanghai) was introduced into the plateau environment (3460m above sea level) Changes in the content of immune active substance (βp-EPLI). The results showed that there was a significant decrease of β-EP in the pituitary (P <0.01) compared with the plain control group in the plateau 24-hour acute acclimation period. The content of β-EP in striatum, hypothalamus, thalamus, bridge extension, hippocampus and midbrain increased significantly (P <0.01). This confirmed that acute hypoxia environment can affect the secretion and release of pituitary β-EP. Tip, brain β-EPLI involved in plateau hypoxia stress response process. It may act as a neurotransmitter and a mediator in the stress response through the neuro-endocrine loop. Β-EP may be one of the major stress hormones in the central nervous system to regulate stress response.