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目的通过对正常儿童与弱视儿童的颜色视觉诱发电位的对比分析,探讨颜色视觉诱发电位对弱视的临床应用价值。方法弱视儿童35名,正常儿童40名,分别进行左右眼的等亮度的黑-白、红-白、绿-白、蓝-白色棋盘格的图形翻转视觉诱发电位,并使用俞自萍设计的5色盲检查图分别检查受检者的色觉,记录结果并分析。结果(1)正常眼的颜色VEP的P1波的振幅以红-白刺激的振幅为最高,其次为蓝-白,再次为黑-白,绿-白刺激的振幅最低;P1波的潜伏期以红-白刺激的潜伏期为最短,其次为蓝-白,再次为黑-白,绿-白的潜伏期最长。(2)弱视组的VEP四种刺激的P1波的振幅均值均较正常组为低,P1波的潜伏期均值均较正常组延长。(3)弱视组的P1波的振幅降低:黑-白刺激与蓝-白刺激有显著性差异,红-白刺激与绿-白刺激无显著性差异;弱视组P1波的潜伏期延长:黑-白刺激无显著性差异,红-白、绿-白、蓝-白刺激均有显著性差异。(4)弱视组无色觉异常病例。结论(1)颜色VEP检查可作为弱视诊断的客观检查。(2)用蓝-白刺激的颜色VEP检查比常用的黑-白刺激的VEP检查更具合理性。(3)中心注视的弱视眼无色觉异常。
Objective To compare the color visual evoked potentials of normal children and amblyopic children and explore the clinical value of color visual evoked potential in amblyopia. Methods 35 children with amblyopia and 40 normal children were enrolled in this study. Visual evoked potentials of black-white, red-white, green-white and blue-white checkerboards with left and right eyes were respectively inverted. Check the chart to examine the subject’s color vision, record the results and analysis. Results (1) The amplitude of P1 wave of VEP with normal eye color showed the highest amplitude of red-white stimulation, the next was blue-white, the second was black-white and the amplitude of green-white stimulation was the lowest. The latency of P1 wave was red - The white incubation period is the shortest, followed by blue - white, black again - white, green - white longest incubation period. (2) The mean amplitude of P1 wave amplitude of VEP in amblyopic group was lower than that in normal group, and the average value of P1 wave latency was longer than that of normal group. (3) The amplitude of P1 wave decreased in amblyopic group: there was a significant difference between black-white stimulation and blue-white stimulation, but there was no significant difference between red-white stimulation and green-white stimulation; There was no significant difference between white stimulus, red - white, green - white, blue - white stimuli were significantly different. (4) amblyopic visual acuity cases. Conclusion (1) Color VEP examination can be used as an objective examination of amblyopia. (2) Color-VEP tests with blue-white stimuli are more plausible than common black-white stimulated VEP exams. (3) amblyopia eyes amblyopic eye gaze abnormalities.