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目的探讨妊高征患者血浆P-选择素含量的变化及其在妊高征发病中的意义。方法采用酶联免疫吸附法测定50例妊高征患者(HDP组),其中妊娠期高血压组12例,轻度子痫前期组20例,重度子痫前期组18例、50例正常晚孕妇女(对照组)血浆P-选择素。结果 HDP组血浆P-选择素值(75.26±24.56μg/l)显著高于对照组(46.24±12.02μg/l)(P<0.001),以子痫前期组增高明显。结论妊高征患者血浆P-选择素水平含量变化与妊高征发病及病情发展有关。
Objective To investigate the changes of plasma P-selectin levels in patients with pregnancy induced hypertension and its significance in the pathogenesis of pregnancy-induced hypertension. Methods 50 patients with PIH (HDP group) were detected by enzyme linked immunosorbent assay (ELISA), including 12 cases of gestational hypertension group, 20 cases of mild preeclampsia group, 18 cases of severe preeclampsia group and 50 cases of normal late pregnant women Female (control group) plasma P-selectin. Results The plasma P-selectin level of HDP group was significantly higher than that of control group (75.26 ± 24.56μg / l) (46.24 ± 12.02μg / l) (P <0.001), and significantly increased in preeclampsia group. Conclusion The changes of plasma P-selectin level in patients with PIH are related to the pathogenesis and progression of PIH.