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本组132例胃癌中有47例雌激素受体(ER)阳性(35.7%);68例大肠癌中有35例ER阳性(52%)。ER阳性率与患者年龄及性别无关,BOrrmann’sⅣ型与低分化及伴有肝转移胃癌ER阳性率明显增高(P<0.05)。68例大肠癌中直肠及左半结肠癌ER阳性率高于右半结肠癌,高分化腺癌ER阳性率高于中、低分化,两者均无统计学意义(P>0.05)。研究表明了消化道肿瘤中存在ER,为今后内分泌治疗提供依据。
Of the 132 patients with gastric cancer, 47 were positive for estrogen receptor (ER) (35.7%); 35 of 68 patients with colorectal cancer were ER-positive (52%). The positive rate of ER was not related to the age and gender of the patients. The positive rate of ER positive in BOrrmann’s type IV and poorly differentiated and liver metastases was significantly higher (P<0.05). In 68 cases of colorectal cancer, the positive rate of ER in rectal and left colon cancer was higher than that in right colon. The positive rate of ER in well-differentiated adenocarcinoma was higher than that in medium and poor differentiation. There was no significant difference between them (P>0.05). Studies have shown that ER exists in the digestive tract tumors, providing a basis for future endocrine therapy.