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本研究对1448例名河南省食管癌高发区农村自然人群中进行了Barrett’s食管的内镜普查和病理组织学检查。同时对1991～1995年门诊病人中Barrett’s食管的检出率进行总结。用免疫组织化学染色法检测了P53、EGFr在Barrett’s食管中的表达。结果显示：自然人群中Barrett’s食管的患病率为0．69％，返流性食管炎的检出率8．9％。门诊病人中Barrett’s食管检出率为1．6％。p53阳性表达率为29％、EGFr为56％。研究表明Barrett’s食管中p53、EGFr的阳性表达是一种很早的生物学改变，其实际意义需长期的随访研究来确定。
In this study, Barrett’s esophageal endoscopy and histopathological examinations were performed in 1448 natural rural populations with high incidence of esophageal cancer in Henan Province. At the same time, the detection rate of Barrett’s esophagus in outpatients from 1991 to 1995 was summarized. The expression of P53 and EGFr in Barrett’s esophagus was detected by immunohistochemical staining. The results showed that the prevalence of Barrett’s esophagus in natural population was 0.69%, and the detection rate of reflux esophagitis was 8.9%. Barrett’s esophageal detection rate was 1.6% in outpatients. The positive rate of p53 expression was 29% and EGFr was 56%. Studies have shown that the positive expression of p53 and EGFr in Barrett’s esophagus is an early biological change, and its actual significance needs to be determined by long-term follow-up studies.