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目的 了解多中心协作化疗方案（MCP方案）对急性淋巴细胞白血病（ALL）和非霍奇金淋巴瘤（NHL）患儿肾脏功能的影响。方法 采用自身叶照法对序贯入院实施MCP化疗的ALL33例和NHL19例患儿肾功能进行多参数监测,包括血清BUN、Cr、Ccr、血、尿β2-MG、尿Alb、TRF、IgG、RBP等。结果 同化疗前比较,化疗后患者血BUN、Cr、Ccr大多正常,仅9例出现镜下血尿或轻度蛋白尿;血、尿β2-MG及尿Alb、RBP显著升高（P<0.05）,而尿TRF和IgG则无明显升高（P>0.05）。结论 MCP方案对ALL和NHL患儿的肾脏功能有一定程度的损害,以尿RBP舍量升高为主要标志的肾小管损害为主,但均处于亚临床状态;是否呈可逆性改变,有待于长期随访。
Objective To investigate the effect of multi-center collaborative chemotherapy (MCP) on renal function in children with acute lymphoblastic leukemia (ALL) and non-Hodgkin’s lymphoma (NHL). Methods The renal function of ALL33 and NHL patients undergoing chemoradiotherapy with sequential chemotherapy were monitored by autotriuma method for multiple parameters, including serum BUN, Cr, Ccr, blood, urinary β2-MG, urinary Alb, TRF, IgG, RBP and so on. Results Compared with those before chemotherapy, the levels of BUN, Cr and Ccr in the blood of patients were mostly normal after chemotherapy. Only 9 cases had microscopic hematuria or mild proteinuria; the blood, urine β2-MG and urinary Alb and RBP were significantly increased (P <0.05) , While urinary TRF and IgG were not significantly increased (P> 0.05). Conclusion The MCP regimen has a certain degree of renal function impairment in children with ALL and NHL. The tubular lesion with the increase of urinary RBP as the main marker is predominant, but all of them are in the subclinical state. Whether they are reversible or not remains Long-term follow-up.