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目的观察螺内酯联合卡维地洛治疗难治性高血压的效果。方法 102例难治性高血压患者随机分为对照组和治疗组,两组均给予基础治疗,对照组给予卡维地洛,治疗组在对照组基础上给予螺内酯。结果对照组总有效率为58.8%,治疗组总有效率为92.2%,两组比较差异有统计学意义(P<0.05)。两组治疗后血压比较差异有统计学意义(P<0.05)。结论螺内酯联合卡维地洛治疗难治性高血压可有效降低血压,临床疗效满意,值得临床推广应用。
Objective To observe the effect of spironolactone combined with carvedilol on refractory hypertension. Methods A total of 102 patients with refractory hypertension were randomly divided into control group and treatment group. Both groups received basic treatment. The control group received carvedilol. The treatment group received spironolactone on the basis of the control group. Results The total effective rate of the control group was 58.8%, the total effective rate of the treatment group was 92.2%, the difference between the two groups was statistically significant (P <0.05). There was significant difference in blood pressure between the two groups after treatment (P <0.05). Conclusion Spironolactone combined with carvedilol in the treatment of refractory hypertension can effectively reduce blood pressure, satisfactory clinical efficacy, it is worthy of clinical application.