前列腺素(PG)在各脏器中均有产生,但以肾脏的髓质和皮质最丰富,前列环素(PGI_2)主要在动脉、小动脉的内皮细胞,鲍氏囊上皮细胞和系膜细胞等处产生。在肾脏灌流压低下时,PG的产生亢进以主动调节肾脏血流量(RBF)和肾小球滤过率(GFR),当用清炎痛等PG抑制剂时,可使RBF和GFR显著下降,在系统性红斑狼疮、肾病综合征、肝硬化合并腹水以及Bartter综合征等患者给予消炎痛时,肌酐廓清率 Prostaglandin (PG) is produced in all organs, but is the most abundant in the medulla and cortex of the kidney. PGI2 is mainly found in the arterial, arteriolar endothelial cells, the Bowman’s capsule epithelial cells and mesangial cells Produced. When the renal perfusion is depressed, the production of PG is hyperthyroidized to actively regulate the renal blood flow (RBF) and glomerular filtration rate (GFR). When PG inhibitors such as Qingyan Hu is used, the RBF and GFR can be significantly decreased, When indomethacin is given to patients with systemic lupus erythematosus, nephrotic syndrome, cirrhosis with cirrhosis and Bartter syndrome, the creatinine clearance rate