糖基化作为蛋白质翻译后修饰的重要形式之一,对理解生命现象非常重要。将细胞质内的单糖核苷酸输送进糖链合成场所高尔基复合体和内质网腔内的物质称为单糖核苷酸转运蛋白(NSTs)。NSTs是由320~400个氨基酸组成的巯水性蛋白质,具有6~10个跨膜结构域。大部分NSTs定位于Golgi复合体膜上,另有一小部分定位于ER膜上。NSTs不仅参与多种遗传性疾病和结缔组织病的发生,而且与肿瘤的发生关系密切。 Glycosylation, one of the important forms of post-translational modification of proteins, is very important for understanding the phenomenon of life. The substance that transports the cytoplasmic monosaccharide nucleotides into the Golgi complex and the endoplasmic reticulum lumen is called monosaccharide nucleotide transporter (NSTs). NSTs are thiohydrins of 320 to 400 amino acids with 6 to 10 transmembrane domains. Most of the NSTs are located on the Golgi complex membrane, with a small proportion located on the ER membrane. NSTs not only involved in a variety of genetic diseases and connective tissue diseases, but also with the occurrence of the tumor closely.