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目的:观察外源性肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征的效果。方法:17例患儿应用PS治疗,观察用药后临床症状、血气分析及机械通气参数的变化。结果:应用PS后患儿呼吸困难、呻吟、三凹征、紫绀症状减轻或消失,用药后监测2h、6h、12h动脉血气分析示PaO2升高、pH值升高、PaCO2下降,与用药前比较,二者之间差异有显著性意义(P<0.05);辅助机械通气治疗患儿用药后30min均下调呼吸机参数;FiO2、PIP、PEEP、RR在用药后2h、6h、12h均显著下降,与用药前比较,差异有显著性意义(P<0.05)。结论:PS治疗新生儿呼吸窘迫综合征疗效确切,可有效改善患儿的肺氧合功能,降低机械通气参数,缩短机械通气治疗时间,减少住院天数、降低病死率。
Objective: To observe the effect of exogenous pulmonary surfactant (PS) on neonatal respiratory distress syndrome. Methods: 17 cases of children treated with PS, observed after treatment of clinical symptoms, blood gas analysis and mechanical ventilation parameters. Results: After treatment with PS, dyspnea, moan, three concave signs and symptoms of cyanosis were alleviated or disappeared. Arterial blood gas analysis at 2h, 6h and 12h after treatment showed that PaO2 increased, pH increased, PaCO2 decreased, compared with before treatment (P <0.05). The parameters of ventilator were all reduced 30 min after auxiliary mechanical ventilation treatment in children, and the values of FiO2, PIP, PEEP and RR decreased significantly at 2 h, 6 h and 12 h after treatment, Compared with before treatment, the difference was significant (P <0.05). Conclusion: PS treatment of neonatal respiratory distress syndrome is effective, which can effectively improve the pulmonary oxygenation in children, reduce the parameters of mechanical ventilation, shorten the duration of mechanical ventilation, reduce the length of hospital stay and reduce the mortality.