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目的 :ＥＢ病毒是一类与鼻咽癌等肿瘤密切相关的ＤＮＡ致瘤病毒 ,其具体致瘤机制至今未明。ＥＢ病毒编码的潜伏膜蛋白 1 (ＬＭＰ1 )被确证具有瘤基因功能 ,它所介导的信号传导途径 ,尤其是ＬＭＰ1通过活化核转录因子ＮＦ κＢ调控下游靶基因的表达 ,在细胞增殖、分化、转化与凋
OBJECTIVE: Epstein-Barr virus (EBV) is a type of DNA oncogenic virus which is closely related to tumors such as nasopharyngeal carcinoma. The specific tumorigenic mechanism is unknown so far. Epstein-Barr virus encoded latent membrane protein 1 (LMP1) has been confirmed to have oncogene function. Its signaling pathway, especially LMP1, regulates the expression of downstream target genes by activating nuclear factor NF-κB, Transformation and withered