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为探讨结核菌素试验复强反应免疫机理，我们在对河南省禹州市神地区常住人口３８９７人作了结核菌素（ＰＰＤ人型）皮试调查。试验分四组，即试验前组、皮试阴性组、皮试阳性组及复强反应组。随机抽样作外周血免疫学检测，结果显示：复强反应组与其他组相比，ＣＤ－３、ＣＤ－４阳性率均有所升高（Ｐ＜０．０５），但ＣＤ－４／ＣＤ－８比值无显著性差异（Ｐ＞０．０５）：血清免疫球蛋白及Ｃ－３测定，复强反应组ＩｇＭ高于皮试前及阴性组，但无统计学意义（Ｐ＞０．０５）；血清ＳＩＬ－２Ｒ检测，各组均比皮试前组升高，尤以复强反应组与皮试前组或阴性组比较为甚（Ｐ＜０．００１）；结核特异抗体测定复强反应组虽有升高，但与皮试前或阴性组相比差异不显著（Ｐ＜０．０５）；特异性结核循环免疫复合物测定，复强反应组与皮试前组及阴性组相比有显著性差异（Ｐ＜０．００１）。揭示复强反应的免疫机理很可能是ＰＰＤ刺激机体使Ｔ细胞免疫反应为主的特异性回忆应答。
In order to explore the mechanism of tuberculin test in response to anaphylactic reaction, we conducted a skin test (PPD human type) skin test on 3897 permanent residents in the God region of Yuzhou, Henan Province. Tests were divided into four groups, namely the pre-test group, skin test negative group, skin test positive group and the complex reaction group. The results of random immunization showed that the positive rates of CD-3 and CD-4 in the re-energized group were significantly higher than those in other groups (P <0.05), but CD-4 / CD -8 (P> 0.05). IgM was higher in patients with re-energization than that before and after skin test in serum immunoglobulin and C-3, but no significant difference (P> 0.05) ). Serum SIL-2R levels were significantly higher in each group than in the former group (P <0.001), especially in the group of rejuvenation and skin test (P <0.001) Although the reaction group was elevated, but no significant difference compared with the skin test before or after the negative group (P <0.05); specific tuberculosis immune complexes, complex reaction group and skin test before the group and the negative group There was significant difference (P <0.001). Reveal the immune response mechanism is likely PPD stimulus T cell immune response-based specific memory response.